Boris Johnson has said he will run to be leader of the Conservative Party.
The former foreign secretary told a conference in Manchester that he would enter the race to succeed Theresa May if a vacancy arises.
The prime minister has promised to step down if parliament ratifies her Brexit deal.
But she is refusing to name a departure date until then.
Mrs May is immune to ousting by Tory MPs until December 2019 – after winning a vote of confidence last year.
Some backbenchers are trying to change the rules so another vote can be held more quickly, while others – including her former co-chief of staff – are calling for her to go.
Mr Johnson was picked as one of the leaders of the Vote Leave campaign for Mrs May’s cabinet when she took over in the aftermath of the 2016 referendum.
He was foreign secretary for two years, before quitting over the “Chequers proposal” – Mrs May’s plan for the future UK-EU relationship after Brexit.
The Uxbridge and South Ruislip MP was also followed out of the cabinet by then-Brexit secretary David Davis
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