{"id":127482,"date":"2021-06-03T18:08:22","date_gmt":"2021-06-03T18:08:22","guid":{"rendered":"https:\/\/precoinnews.com\/?p=127482"},"modified":"2021-06-03T18:08:22","modified_gmt":"2021-06-03T18:08:22","slug":"novartis-nuclear-therapy-helps-men-with-prostate-cancer-live-longer-data","status":"publish","type":"post","link":"https:\/\/precoinnews.com\/markets\/novartis-nuclear-therapy-helps-men-with-prostate-cancer-live-longer-data\/","title":{"rendered":"Novartis' nuclear therapy helps men with prostate cancer live longer – data"},"content":{"rendered":"

ZURICH (Reuters) – Men with a deadly form of advanced prostate cancer who failed other treatments survived four months longer after getting an experimental, tumour-targeting radiation therapy from Swiss drugmaker Novartis, data released on Thursday showed.<\/p>

FILE PHOTO: The company’s logo is seen at the new cell and gene therapy factory of Swiss drugmaker Novartis in Stein, Switzerland, November 28, 2019. REUTERS\/Arnd Wiegmann\/File Photo<\/figcaption>

The company\u2019s Lu-PSMA-617 therapy boosted median overall survival (OS) to 15.3 months in patients with metastatic castration-resistant prostate cancer, according to data released at the 2021 American Society of Clinical Oncology annual meeting.<\/p>\n

That compared with 11.3 months for men who got standard care.<\/p>\n

Men who got the treatment also lived a median 8.7 months without their cancer progressing, more than double the 3.4-month progression free survival (PFS) of those who did not get it, the data showed.<\/p>\n

Novartis announced the drug extended survival in March, but this is the first time specific figures have been released.<\/p>\n

The therapy attaches a radioactive isotope, lutetium-177, with a half-life of less than seven days to a small molecule drug, PSMA-617, that binds to an antigen expressed in large amounts by prostate cancer cells, with the aim of killing them in a targeted way while limiting damage to surrounding, healthy cells.<\/p>\n

\u201cThis work represents a transformation in care for individuals with metastatic castration-resistant prostate cancer,\u201d said Dr. Michael Morris, a prostate cancer specialist at Memorial Sloan Kettering Cancer Center in New York, who chaired the study\u2019s scientific committee.<\/p>\n

The Swiss-based drugmaker plans to file Lu-PSMA-617 for approval this year.<\/p>\n

Novartis, which got the therapy when it bought Endocyte three years ago for $2.1 billion, has a growing cabinet of radioligand medicines that also includes already approved Lutathera.<\/p>\n

Prostate cancer can often be treated via surgery, radiation therapy or hormone therapy that stops tumour-driving testosterone from being produced or reaching prostate cancer cells.<\/p>\n

Metastatic castration-resistant prostate cancer, however, resists such hormone treatment, making it tough to treat — and a potentially lucrative target. Novartis eventually sees Lu-PSMA-617 topping $1 billion in sales annually.<\/p>\n

\u201cMen with metastatic prostate cancer have an approximately three in 10 chance of surviving five years,\u201d John Tsai, Novartis\u2019s top drug developer, said, adding the data released on Thursday confirm the therapy\u2019s prospects as a new option to help increase the survival rate.<\/p>\n

Source: Read Full Article<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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